MUSCULAR DYSTROPHY

Muscular Dystrophy is a Musculoskeletal disease that consists of progressive muscle weakness, loss of muscle mass, frequent falls, intellectual disabilities, and gait disturbances, It affects in all age groups and is mainly seen in boys. There are numerous types of muscular dystrophy among them Duchene Muscular Dystrophy ( DMD) is commonest one.

Muscular Dystrophy is caused by mutations in the gene responsible for healthy muscle structure and function. Mutation means cells that should maintain your muscles can no longer fulfil their role, which will lead to muscle weakness and progressive disability. The protein associated with the DMD gene was identified and named as Dystrophin. It is located in the short arm of the X chromosome, in the Xp21. Mutated DMD gene fails to The protein associated with the DMD gene was identified and named as Dystrophin. It is located in the short arm of the X chromosome, in the Xp21. Mutated DMD gene fails to produce any functional dystrophin. Dystrophin act as a membrane stabilizer during muscle contraction to prevent contraction-induced damage .Lack of production of dystrophin will leads to progressive muscle weakness.